I did some testing with negative results for load sensivity changes on 'fuel load penalization' subject.
I made unloaded and loaded laps with these tyre values
LoadSensLat=(-4e-6, 0.36, 23400) // initial tyre load sensivity >>> this gives fuel load sensivity: 60% of real
LoadSensLong=(-4e-6, 0.43, 23400)
and then the same with these:
LoadSensLat=(-22e-6, 0.12, 14350) // much higher tyre load sensivity
LoadSensLong=(-22e-6, 0.15, 14350)
I guess last values i used were already too extreme, because i had to compensate big loss of grip with very high drylatlong values to get the same lap times on empty tank.
As i expected I also noticed wing setting changes hasn't almost any effect on grip or car balance, suffering big oversteer on high speeds, but more rear wing and less front wing didn't help.
However, even with such high load sensivity, lap time difference between loaded (210liters) and empty fuel tank were almost the same than before (3-3.5secs on Interlagos).
So, I would say tyre load sensivity is not the (only) problem.